| Statistic | Value | Team | Date & Opponent |
|---|---|---|---|
| Most Points | 73 | Houston | 11/28/2009 Rice |
| Largest Margin | 59 | Florida Houston | 11/21/2009 Florida International
11/28/2009 Rice |
| Fewest Rushing Yards | -54 | Washington St. | 10/10/2009 Arizona St. |
| Most Rushing Yards | 574 | Nevada | 11/21/2009 @ New Mexico St. |
| Fewest Passing Yards (>9 att.) | 1 | Ball St. | 10/24/2009 @ Eastern Michigan |
| Most Passing Yards | 578 | Houston | 11/21/2009 Memphis |
| Fewest Total Rushing Yards | -11 | Tulane | 11/21/2009 @ Central Florida |
| Most Total Rushing Yards | 574 | Nevada | 11/21/2009 @ New Mexico St. |
| Fewest Total Passing Yards (>9 att.) | -15 | Ball St. | 10/24/2009 @ Eastern Michigan |
| Most Total Passing Yards | 573 | Houston | 11/21/2009 Memphis |
| Fewest Total Yards | 50 | Tulane | 11/21/2009 @ Central Florida |
| Most Total Yards | 773 | Nevada | 10/03/2009 UNLV |
| Most Fumbles | 7 | Washington St. Syracuse Nebraska Rice | 09/12/2009 vs. Hawaii
09/19/2009 Northwestern 10/24/2009 Iowa St. 10/24/2009 Central Florida |
| Most Fumbles Lost | 5 | Purdue Nebraska UTEP Arizona St. | 10/03/2009 Northwestern
10/24/2009 Iowa St. 11/21/2009 @ Rice 11/21/2009 @ UCLA |
| Most Interceptions Thrown | 6 | Houston | 12/31/2009 vs. Air Force |
| Most Field Goals Made | 6 | Clemson | 09/19/2009 Boston College |
| Most Field Goals Attempted | 6 | Clemson Air Force Alabama Western Kentucky Central Michigan | 09/19/2009 Boston College
09/26/2009 San Diego St. 09/26/2009 Arkansas 11/14/2009 @ Louisiana-Monroe 01/06/2010 vs. Troy |
| Most Punts | 14 | Oklahoma St. | 11/28/2009 @ Oklahoma |